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sionnach commented on the word haha response
HAHA response: the formation of (Human) Antibodies in response to treatment with a (therapeutic) Humanized Antibody.
Induction of a HAHA response is generally undesirable, as the antibodies formed usually have the potential to neutralize the effect of the treatment antibody. Much care is taken to engineer non-human characteristics out of the treatment antibody as far as possible (hence the term 'humanized antibody'), to minimize the chances of it being perceived as 'foreign', thereby triggering a HAHA response in the subject.
The potential for this kind of unwanted immunogenic response is a major concern in clinical tests to evaluate the potential therapeutic benefit of new designer antibodies. In addition to neutralizing treatment activity, it can have clinical sequelae that are actively harmful to the patient.
Detection and accurate quantification of a HAHA response is notoriously difficult.
This phrase comes up in every team meeting I attend. It gives me nightmares.
April 22, 2008
Prolagus commented on the word haha response
I'm very proud of my list now.
April 22, 2008
reesetee commented on the word haha response
So the HAHA response isn't very funny, sionnach?
April 22, 2008
bilby commented on the word haha response
*glances at St Louis*
March 9, 2009
Prolagus commented on the word haha response
http://www.sciencedirect.com/science/article/pii/S0731708509004725
January 18, 2013